The majority of biologically active compounds derived from spices are anti-oxidant and anti-inflammatory; so besides giving flavour to foods, spices possess potential health benefits. Curcumin is a natural, herbal extract of the root used to produce the spice Turmeric. Turmeric has been used for thousands of years in the Ayurvedic system of medicine. Curcumin makes up about 2 to 5% of turmeric and consists of a number of biologically active compounds known as the curcuminoids. Fifty years of scientific research can be accessed via www.google.com and www.pubmed.gov
To address bioavailability, we have used a lipidized co-factor enhanced Curcuminoid (C3) Complex formulation.
Global research into Curcumin’s effects continues to produce promising findings regarding its efficacy in a range of inflammatory conditions. The most active area of research relates to its use as a complimentary medicine in arthritis and cancer treatments. Anecdotally, NatureWise Health has used CurcumaGen to good effect in several areas:
CurcumaGen is contract manufactured for NatureWise Health by PharmaNatura as a softgel capsule according to Good Manufacturing Practices (GMP). This ensures the highest standards of quality control in blending, product testing and encapsulation.
CurcumaGen should be taken on an empty stomach. It is essential that optimal daily intake of water is maintained. A general guideline for dosage is 3-4 capsules per day,
1-2 before breakfast, 2 before dinner. This approach is typically effective for arthritis, lower back ache and joint pain. Some conditions may require higher dosages and referral to the scientific literature would be advised.
Studies have shown that dosages as high as 12g of curcumin per day are well tolerated.
Yes. CurcumaGen has a NAPPI code, which enables General Practitioners to prescribe the product, and any user of CurcumaGen to claim the cost from their medical aid.
CurcumaGen is registered with the SA MCC as a Complimentary Medicine.
There is growing evidence that inflammation plays a critical role in chronic disease. Nuclear Factor kappa-B (NF-κB), the body’s master inflammation switch, is linked to a wide range of diseases. NF-κB, is found in the cytoplasm of the cell. In the presence of free radicals, pollutants, viruses, bacteria etc, NF-κB moves into the nucleus to activate inflammation and protective responses. Inflammatory responses, acute or chronic, include the release of enzymes (for e.g. COX-2), cytokines, leukotrienes, histamines, etc.
Curcumin 'down' regulates inflammatory responses and 'up' regulates the cells protective and anti-oxidant responses. Curcumin’s broad effectiveness is a direct result of its unique ability to interact with up to 300 biochemical pathways in the body. Another key feature is the fact that inhibition of NF-κB, COX-2, LOX etc. does not impact COX-1, thereby not impacting the stomach’s mucus lining.
Curcumin is also an antioxidant, up to 8x more effective than Vitamin E. So-called free radicals cause damage to the body in numerous ways and curcumin protects the body by mopping up free radicals.
The literature on Curcumin is extensive. Below are a few easy reading articles.
Slowing ageing and postponing the onset of age-related diseases may be achieved by blocking the NF-kappaB-dependent inflammation.
Curry Consumption and Cognitive Function in the Elderly; The authors reported tentative evidence of better cognitive performance from curry consumption in non-demented elderly Asians, which should be confirmed in future studies
Curcumin is a strong candidate for use in the prevention or treatment of major disabling age-related neurodegenerative diseases like Alzheimer’s, Parkinson’s, and stroke. Promising results have already led to ongoing pilot clinical trials
The present cases suggest a significant improvement of the behavioral symptoms in the AD with the turmeric treatment, leading to probable benefit of the use of turmeric in individuals with the AD with BPSD (Behavioral and Psychological Symptoms of Dementia)
This review article revisits and presents the current research done on the potential of the curcuminoids (curcumin and demethoxycurcumin) and the polyphenolic compound resveratrol as anti-AD compounds
The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.
Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-: modulating and neuroprotective effects; With increasing interest in natural treatments for depression, and efforts to enhance current treatment outcomes, curcumin is presented as a promising novel, adjunctive or stand-alone natural antidepressant.
Curry Consumption and Cognitive Function in the Elderly; The authors reported tentative evidence of better cognitive performance from curry consumption in nondemented elderly Asians, which should be confirmed in future studies
Curcumin has been shown to mop-up free radicals
Curcumin has been shown to be as effective as non-steroidal anti-inflammatories, without the side effects.
Scientific Evidence and Rationale for the Development of Curcumin and Resveratrol as Nutraceutricals for Joint Health; This paper critically reviews the recent literature and outlines the potential prophylactic properties of plant-derived phytochemicals such as curcumin and resveratrol for targeting NF-κB signaling and inflammation in OA to determine whether these phytochemicals can be used as functional foods
A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis; Our study provides the first evidence for the safety and superiority of curcumin treatment in patients with active RA, and highlights the need for future large-scale trials to validate these findings in patients with RA and other arthritic conditions
NF-kB and its relevance to arthritis and inflammation; The importance of NF-kappaB in inflammation is undisputed and inhibition of the pathway is widely believed to have great potential as a therapeutic target in RA.
This is the broadest and deepest area for clinical research globally. Strong evidence has emerged for curcumin as an agent that can significantly enhance the effectiveness of chemotherapy, whilst providing radio-protective benefits
Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2; In conclusion, chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive pro-inflammatory and pro-metastatic feed-back loop between NFκB and CXCL1/-2. Curcumin disrupts this feed-back loop by the inhibition of NFκB signalling leading to reduced metastasis formation in vivo.
Curcumin and cancer: An ‘‘old-age” disease with an ‘‘age-old” solution; The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an ‘‘old-age” disease such as cancer requires an ‘‘age-old” treatment
Curcumin has a great potential in cancer therapy and is gaining wide acceptance as a preventive treatment agent due to its safety. It affects multiple steps in the carcinogenic process, which is important in avoiding chemoresistance. Clinical studies have indicated its efficacy as a single agent or in combination therapy; however, more rigorous testing are needed
Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells.
Long term use of curcumin in two smouldering multiple myeloma patients; Both patients showed continued improvement in a number of markers of disease activity including serum free light chains, paraprotein and % plasma cells in the bone marrow. These results suggest that patients with smouldering myeloma may benefit from daily ingestion of curcumin and long term use does not result in toxicity.
Curcumin may match exercise for heart health benefits.
Some studies demonstrate that curcumin reduced total cholesterol level and LDL cholesterol levels.
Our findings suggest that inhibition of SR-A-mediated oxLDL uptake and promotion of ABCA1-dependent cholesterol efflux are two crucial events in suppression of cholesterol accumulation by curcumin in the transformation of macrophage foam cells.
Curcumin regulates the master molecule for inflammation.
Nuclear Factor-kB Activation: From Bench to Bedside; Suppression of constitutive NF-kB activation inhibits the oncogenic potential of transformed cells and thus makes NF-kB an interesting new therapeutic target in cancer
In mouse models, inhibition of NF-kB leads to delayed onset of age-related symptoms and pathologies. In addition, NF-kB activation is linked with many of the known lifespan regulators including insulin/IGF-1, FOXO, SIRT, mTOR, and DNA damage. Thus NF-kB represents a possible therapeutic target for extending mammalian healthspan.
Curcumin improves results when used in conjunction with conventional medication.
Curcumin for Inflammatory Bowel Disease: A Review of Human Studies; Although two small studies have shown promising results, all authors conclude that larger-scale, double-blind trials need to be conducted to establish a role for curcumin in the treatment of ulcerative colitis. In addition to improving results when used in conjunction with conventional medications for UC, curcumin may pose a less-expensive alternative.
CURCUMIN: THE INDIAN SOLID GOLD; Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses
Curcumin: From ancient medicine to current clinical trials; Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer's disease.
Therapeutic potential of curcumin in medicinal chemistry; The present review has been devoted towards better understanding of the phytonutraceutic properties of curcumin and turmeric based on their disease specific indications and enhancing their prophylactic and therapeutic nutraceutical qualities. The article deals with the biological activity, mode of action, toxicity and forthcoming application of these leads.
Curcumin and Its Emerging Role in Pain Modulation and Pain Management; Clearly, curcumin has significant anti-nociceptive properties. Further large scale studies are needed in humans to fully elaborate and harness the pain mitigating effects of curcumin.
Curcumin can be taken internally or applied topically to benefit the skin. It is able to protect the skin from damage caused by free radicals and curb inflammation due to its ability to inhibit specific inflammatory signaling pathways that cause damage