CurcumaGen

Natures finest Anti-Inflammatory

An Extract of Turmeric

The majority of biologically active compounds derived from spices are anti-oxidant and anti-inflammatory; so besides giving flavour to foods, spices possess potential health benefits. Curcumin is a natural, herbal extract of the root used to produce the spice Turmeric. Turmeric has been used for thousands of years in the Ayurvedic system of medicine. Curcumin makes up about 2 to 5% of turmeric and consists of a number of biologically active compounds known as the curcuminoids. Fifty years of scientific research can be accessed via www.google.com and www.pubmed.gov

Unique to CurcumaGen

To address bioavailability, we have used a lipidized co-factor enhanced Curcuminoid (C3) Complex formulation.

Positive Results

Global research into Curcumin’s effects continues to produce promising findings regarding its efficacy in a range of inflammatory conditions. The most active area of research relates to its use as a complimentary medicine in arthritis and cancer treatments. Anecdotally, NatureWise Health has used CurcumaGen to good effect in several areas:

  • Inflammatory conditions including, Arthritis, Acne, Eczema/Psoriasis, Joint Pain/Tennis Elbow/Lower Back Pain.
  • In combination with Xeloda, a chemotherapy agent, to significantly improve the outcomes of an elderly Stage T4 colorectal patient.
  • Reducing cholesterol
  • Improving symptoms for individuals suffering from Motor Neuron Disease (ALS) and Multiple Sclerosis.


Manufacturing:

CurcumaGen is contract manufactured for NatureWise Health by PharmaNatura as a softgel capsule according to Good Manufacturing Practices (GMP). This ensures the highest standards of quality control in blending, product testing and encapsulation.

What are the recommended dosages?

CurcumaGen should be taken on an empty stomach. It is essential that optimal daily intake of water is maintained. A general guideline for dosage is 3-4 capsules per day,
1-2 before breakfast, 2 before dinner. This approach is typically effective for arthritis, lower back ache and joint pain. Some conditions may require higher dosages and referral to the scientific literature would be advised.

Is Curcumin Safe?

Studies have shown that dosages as high as 12g of curcumin per day are well tolerated.

Can I claim it from my medical aid?

Yes. CurcumaGen has a NAPPI code, which enables General Practitioners to prescribe the product, and any user of CurcumaGen to claim the cost from their medical aid.

South African Medicines Control Council Registration

CurcumaGen is registered with the SA MCC as a Complimentary Medicine.

Curcumin 101

Understanding Inflammation

There is growing evidence that inflammation plays a critical role in chronic disease. Nuclear Factor kappa-B (NF-κB), the body’s master inflammation switch, is linked to a wide range of diseases. NF-κB, is found in the cytoplasm of the cell. In the presence of free radicals, pollutants, viruses, bacteria etc, NF-κB moves into the nucleus to activate inflammation and protective responses. Inflammatory responses, acute or chronic, include the release of enzymes (for e.g. COX-2), cytokines, leukotrienes, histamines, etc.

How Curcumin Works

Curcumin 'down' regulates inflammatory responses and 'up' regulates the cells protective and anti-oxidant responses. Curcumin’s broad effectiveness is a direct result of its unique ability to interact with up to 300 biochemical pathways in the body. Another key feature is the fact that inhibition of NF-κB, COX-2, LOX etc. does not impact COX-1, thereby not impacting the stomach’s mucus lining.

Curcumin is also an antioxidant, up to 8x more effective than Vitamin E. So-called free radicals cause damage to the body in numerous ways and curcumin protects the body by mopping up free radicals.

The literature on Curcumin is extensive. Below are a few easy reading articles.

Health Benefits

Click on the field of interest to access detailed scientific research and general articles on Curcumin's roles, effectiveness, mechanisms, and other studies.

Curcumin is a strong candidate for use in the prevention or treatment of major disabling age-related neurodegenerative diseases like Alzheimer’s, Parkinson’s, and stroke. Promising results have already led to ongoing pilot clinical trials

The present cases suggest a significant improvement of the behavioral symptoms in the AD with the turmeric treatment, leading to probable benefit of the use of turmeric in individuals with the AD with BPSD (Behavioral and Psychological Symptoms of Dementia)

This review article revisits and presents the current research done on the potential of the curcuminoids (curcumin and demethoxycurcumin) and the polyphenolic compound resveratrol as anti-AD compounds

dietary curcumin is ......

The study results demonstrated that sulfite-exposure was associated with impaired learning and memory in rats. Adding curcumin to the rat nutrition plays a protective role in learning and memory after exposure to sulfite.

we summarize the recent discoveries of potential antioxidant compounds for modulating free radical mediated oxidative stress leading to neurotoxicity in PD

We review the literature pertaining to these various classes of nutraceutical antioxidants and discuss their potential therapeutic value in neurodegenerative diseases.

Antioxidants like curcumin that prevent the dramatic consequences of reactive oxygen species are considered to be a good approach to neuroprotection

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-: modulating and neuroprotective effects; With increasing interest in natural treatments for depression, and efforts to enhance current treatment outcomes, curcumin is presented as a promising novel, adjunctive or stand-alone natural antidepressant.

Curry Consumption and Cognitive Function in the Elderly; The authors reported tentative evidence of better cognitive performance from curry consumption in nondemented elderly Asians, which should be confirmed in future studies

This is the broadest and deepest area for clinical research globally. Strong evidence has emerged for curcumin as an agent that can significantly enhance the effectiveness of chemotherapy, whilst providing radio-protective benefits

Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2; In conclusion, chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive pro-inflammatory and pro-metastatic feed-back loop between NFκB and CXCL1/-2. Curcumin disrupts this feed-back loop by the inhibition of NFκB signalling leading to reduced metastasis formation in vivo.

Curcumin and cancer: An ‘‘old-age” disease with an ‘‘age-old” solution; The activity of curcumin reported against leukemia and lymphoma, gastrointestinal cancers, genitourinary cancers, breast cancer, ovarian cancer, head and neck squamous cell carcinoma, lung cancer, melanoma, neurological cancers, and sarcoma reflects its ability to affect multiple targets. Thus an ‘‘old-age” disease such as cancer requires an ‘‘age-old” treatment

Is There Any Other Anti-Cancer Botanical Compound As Exciting As Curcumin?

Curcumin has a great potential in cancer therapy and is gaining wide acceptance as a preventive treatment agent due to its safety. It affects multiple steps in the carcinogenic process, which is important in avoiding chemoresistance. Clinical studies have indicated its efficacy as a single agent or in combination therapy; however, more rigorous testing are needed

Recent data suggest that an additional mechanism involved in cancer-related inflammation (CRI) is induction of genetic instability by inflammatory mediators, leading to accumulation of random genetic alterations in cancer cells.

Preclinical Assessment of Curcumin as a Potential Therapy for B-CLL

Curcumin Protects the Brain and Fights Cancer

Cancer-linked targets modulated by curcumin

Inflammation and cancer: How hot is the link? - ResearchGate

Feeling the heat – the link between inflammation and cancer

NF-kB provides a critical link between inflammation and cancer

This review outlines the principal mechanisms that govern the effects of inflammation and immunity on tumor development and discusses attractive new targets for cancer therapy and prevention

Prostate Cancer: Curcumin Curbs Metastases, Study Shows

Long term use of curcumin in two smouldering multiple myeloma patients; Both patients showed continued improvement in a number of markers of disease activity including serum free light chains, paraprotein and % plasma cells in the bone marrow. These results suggest that patients with smouldering myeloma may benefit from daily ingestion of curcumin and long term use does not result in toxicity.

Curcumin relieves radiation dermatitis in Breast Cancer

Additional results available in the Journal CARCINOGENESIS (296 PAPERS AVAILABLE)

This article reviews the use of curcumin for the chemoprevention and treatment of various diseases.

Inflammation 101

http://www.integrativeoncology-essentials.com/2012/11/inflammation-101-the-fuel-that-feeds-cancer/

CURCUMIN: THE INDIAN SOLID GOLD; Extensive research within the last half century has proven that most of these activities, once associated with turmeric, are due to curcumin. Curcumin has been shown to exhibit antioxidant, anti-inflammatory, antiviral, antibacterial, antifungal, and anticancer activities and thus has a potential against various malignant diseases, diabetes, allergies, arthritis, Alzheimer’s disease, and other chronic illnesses

Various pharmacological aspects of curcumin in vitro and in vivo are discussed in detail here.

Curcumin and curcuminoids in quest for medicinal status;

Curcumin (diferuloylmethane) inhibits constitutive NF-kB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma

Potential therapeutic effect of curcumin - an update

Curcumin: From ancient medicine to current clinical trials; Curcumin exhibits great promise as a therapeutic agent, and is currently in human clinical trials for a variety of conditions, including multiple myeloma, pancreatic cancer, myelodysplastic syndromes, colon cancer, psoriasis and Alzheimer's disease.

Therapeutic potential of curcumin in medicinal chemistry; The present review has been devoted towards better understanding of the phytonutraceutic properties of curcumin and turmeric based on their disease specific indications and enhancing their prophylactic and therapeutic nutraceutical qualities. The article deals with the biological activity, mode of action, toxicity and forthcoming application of these leads.

Retailers

SANDTON Nutribalance

011 884 8753

BRYANSTON Fruits and Roots

011 463 2928

Dr. Murray Rushmere, Observatory, CPT

021 448 4693

Dr. Marion Weston, Tokai, CPT

021 823 8590

Dr. Hester Visagie, Allens Nek, Gauteng

011 679 5924

Contact Us

NatureWise Health Customer Care Line

0769117470

Fax Number

0866449808

Email

care@curcumin.co.za

orders@curcumin.co.za

Copyright 2013

Disclaimer:

The product and website do not intend to diagnose, treat, cure or prevent disease. The information provided is for informational purposes only. You should consult with a healthcare professional before starting any diet, exercise or supplementation programme.